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The result is more side effects with no extra benefit
Taking these drawbacks into consideration, the prodrugs of EGCG analogs were synthesized with the compounds identified as 2a and 4a having lower susceptibility to be metabolized or inhibited by COMT and having an amplified antiproliferative, antiangiogenic, and antifibrotic effect in HuLM ( Scutellaria barbata D
Additionally, GSH can be regenerated from GSSG by glutathione reductases (GR)
Another report suggested that FSP1/CoQ10/NADPH and GSH/GPX4 pathways were compromised in RPE cells treated with NaIO 3 , which was exacerbated by silencing FSP1 and GPX4 (85)
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