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Funding This work was supported by an NIH (R03AG070540-0) and a VA Merit award (BX004352-01) to LA
Growth hormone secretagogues like MK-677 (a ghrelin receptor agonist) face the same limitation: they cant override elevated somatostatin or suppressed GHRH signaling
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It works by inhibiting the tyrosinase enzyme, which converts dark melanin (eumelanin) to lighter melanin (pheomelanin), resulting in gradual skin brightening and overall detoxification
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