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About 25% of the goopy stuff between our skin cells consists of cholesterol

Pharmacokinetic modeling of the impact of the difference in typical subcutaneous administration volumes between rats (0.5 mL) and humans (1.25 mL), which directly influences the timeframe of hydrogel erosion and drug release, coupled with the much shorter elimination half-life of GLP-1 RAs in rats (semaglutide t 1/2, serum 0.29 days) than in humans (semaglutide t 1/2, serum 7 days), indicated that a once-every-four-month therapeutic in humans would exhibit six weeks of continuous therapy in rats

[1] [37] For other GLP-1 receptor agonists, clinically significant effects on oral contraceptive efficacy have not been demonstrated, but patients should check their specific medication's SmPC

The potential of GLP-1 agonists in weight loss has been a topic of ongoing discussion, but FDA approval for obesity has only been granted in the past decade