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May 2012;23(5):1348-1353
J., Strauss, H
Switch to the 2831 gauge insulin syringe for the actual injection
Long-acting GLP-1R agonists including Semaglutide may produce biased agonism and preferential activation of Gs versus Gq/11 versus beta-arrestin signalling pathways , relative to native GLP-1, with the albumin-bound fatty acid conjugate form potentially modifying the receptor contact geometry in ways that favour specific downstream pathway engagement
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