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Remember that your body needs time to adjust to new hormonal signals, and patience is your best ally during the first few weeks of a new medication
In phase 2 clinical trials published in the New England Journal of Medicine in 2023, participants on the highest dose of retatrutide lost an average of 24.2% of their body weight over 48 weeks
[1] [6] Whilst these reductions are modest, they are clinically meaningful when considered alongside the medication's other cardiovascular benefits
Side Effects Both medications can cause: Nausea Constipation Reflux Fatigue in the beginning Tirzepatide may cause a bit more nausea for some people, but it also seems to be better tolerated in others
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