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There are newer GLP-1-based drugs, including many in development, that are generally more effective at treating obesity and diabetes than semaglutide
The genes exemplified in Figure 4 comprise markers of inflammation and plaque stability that are associated with leukocyte recruitment (e.g., IL-1RN, IL-6, CCL2, OPN), leukocyte adhesion (SELE, VCAM-1), leukocyte extravasation, and plaque stability (e.g., MMP-3, MMP-13, CCL2), and plaque rupture and hemorrhage (CD163)
Persistent high blood sugar, excess abdominal fat, and insulin resistance cause chronic inflammation
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