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As detailed in Canhams analysis, the clinical metrics demonstrate a clear separation between peripheral auditory stabilization and vestibular symptom control: Low-Frequency Pure-Tone Thresholds: Evaluating low-frequency pure-tone thresholds at 250 Hz, 500 Hz, and 1000 Hz revealed that 52.7% of subjects on SPI-1005 achieved a 10 dB or greater improvement in at least one frequency, compared to 37.0% in the placebo group

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(A and B) The level of lipid ROS (oxidized BODIPY-C11 (green)/non-oxidized BODIPY-C11 (red) ratio) detected by using BODIPY-C11 kit in HASMCs with METTL3 overexpression (A) or knockdown (B) which treated with cystine deprivation or IKE (n=4 per group)