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Although SUMMIT also demonstrated a reduction in the composite endpoint of cardiovascular death or worsening HF events, the magnitude of the improvement, specifically in the KCCQ-CSS observed with higher-dose semaglutide (STEP-HFpEF
A systematic review confirmed that NAC improves ovulation rate and hormonal parameters in PCOS (Thakker et al., Obstet Gynecol Int, 2015) [59]
For Study 6, the primary efficacy parameters were mean percent change in body weight and the percentage of patients achieving greater than or equal to 5% weight loss from baseline to Week 68
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