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Various mechanisms, such as glutamate-induced excitotoxicity, mitochondrial dysfunction, neurotoxicity, etc., are associated with the consequences of TBI
There has also been a lot of discussion on whether the benefits last after stopping taking these drugs, especially if no diet or lifestyle changes are made while on them
This will provide us with the information we need to recommend the right dosage
Pignatti says that, in his view, although both agencies consider progression-free survival (PFS) as a reasonably likely surrogate endpoint, we considered that PFS could be a relevant clinical endpoint in its own right this has been clear in our anticancer guideline for many years
