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Under oxidative stress, accumulation of ROS can activate pathways such as the JNK and the p53, further inducing autophagy, which helps clear damaged organelles, reduces oxidative damage, and protects cell survival [256]
As the oxidative burden on the nervous system decreases, the autonomic nervous system can begin to shift back toward parasympathetic dominance (the "rest-and-digest" state)
As LOEs approach, companies that win will be those that convert de-risked science into predictable outcomesnot those that chase breadth
These are likely mechanisms by which GLP-1 may impact neuropsychiatric conditions. Ziyad Al-Aly, MD I think there is clearly (an) added benefit for several conditions
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