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Curr Med Chem 12:11611208 Arslan A, Tzn FA, Tamer S, Demir H, Aycan A, Demir C, Tasin M, Gnll E (2016) Change of antioxidant enzyme activities, some metals and lipid peroxidation in Alzheimers disease

Physical Stimuli Friction or vibration on the skin (i.e., rubbing, tight clothing), and/or intense exercise

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Mechanism of action: melanocortin cAMP/PKA/MITF cascade Presynaptic activation of cutaneous MC1R and central MC3R/MC4R/MC5R PRIMARY PATHWAY MELANOGENESIS MC1R on melanocytes High-affinity binding to the MC1R receptor on epidermal melanocytes