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Synaptic dysfunction in ALS and FTD: Anatomical and molecular changes provide insights into mechanisms of disease

GLP-1 Case Study Name: Richard J., a 58-year-old male Medical History: Type 2 Diabetes Mellitus (diagnosed 7 years ago) Obesity (BMI 35 kg/m) Hypertension (well-controlled on an ACE inhibitor) Mild diabetic retinopathy Current Medications: Metformin 1000 mg twice daily, glimepiride 2 mg once daily, and lisinopril 20 mg once daily Clinical Presentation Richard presents a routine follow-up

Components of the ECS are present in DCs, including CB1 and CB2 in addition to anandamide, 2-AG and FAAH [108]

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