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Their characterization by electrophysiological approaches revealed that they are mostly closed under basal conditions and activated by different stimuli that are also known to induce eryptosis: ROS, exposure to high extracellular osmolarity, or removal of extracellular Cl - and isosmotic replacement with gluconate activate the channel [98] and trigger eryptosis [90]
Because mitochondria lack GSH biosynthetic machinery 5 and GSH is negatively charged under physiological conditions 10 , it must enter mitochondria through a dedicated transport process
JAMA Network, 2022
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