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However, they did admit that the people with MS generally had long-standing, rather than newly diagnosed, disease

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Synaptic dysfunction and neurotransmitter imbalance It has been well established that cholinergic transmission is essential for memory, learning, attention, and other higher brain functions, so cholinergic deficits play a key role in the neuropathology of AD (38)

Investigating Toxic Overload and Depression A targeted history and laboratory assessment may help distinguish environmental exposure from elevated SAH, glutathione depletion, mitochondrial stress, gut-derived burden or impaired organ clearance