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NICE recommends GLP-1 therapy for type 2 diabetes (NG28) when: HbA1c remains elevated despite dual therapy with metformin and another oral agent The patient has a BMI of 35 kg/m or higher (or lower thresholds for certain ethnic groups) Significant weight loss would benefit other obesity-related comorbidities Insulin therapy poses specific risks or is declined by the patient For weight management, NICE has approved specific GLP-1 receptor agonists through Technology Appraisals

The evidence suggests that Inositol, vitamin D, omega-3 fatty acids, coenzyme Q10, curcumin, and oleoyl ethanolamide benefit insulin sensitivity, glucose metabolism, and inflammatory markers

Mantener una ingesta consistente de fibra durante este perodo de adaptacin puede facilitar la transicin y mejorar la adherencia al tratamiento