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These polymorphisms are common in the population and can influence homocysteine levels and methylation efficiency

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Cleavage under targets and tagmentation sequencing (CUT&Tag-seq), chromatin immunoprecipitation with quantitative PCR (ChIPqPCR), and ChIPre-ChIP analyses all revealed the enrichment of H1(N76D/N77D) at the 80 sensitive damaged sites prone to both homologous recombination and non-homologous end-joining (NHEJ) repair pathways (Fig