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These include: pain shooting down the leg (sciatica) numbness or tingling in the arms or legs pain that worsens when sitting pain relieved by lying down weakness in the arms or legs These symptoms may indicate nerve compression from a spinal disc issue

They can rule out underlying causes and personalize a treatment plan

Rhesus macaques were also used to study GLP-1s effects on pancreatic function and glucose metabolism, further validating the drugs mechanism and safety before human trials

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