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If you miss a dose, most protocols suggest taking it as soon as you remember, provided the next scheduled dose is at least 3 days (72 hours) away

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However, there is no evidence that maternal homocysteine is a causative factor in neonatal brain development but measurement of maternal homocysteine concentration may provide an insight into the efficiency of the methionine cycle and provision of methyl groups (one carbon metabolism) during pregnancy

Some newer liposomal and acetylated formulations improve bioavailability, but none reliably match the cellular delivery of a doctor-supervised IV protocol