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doi: 10.1126/science.abf0529 99 TanRWenKZhaoTGuoHHanXWangJet al

2026;49(Suppl 1):S1-S371

When the body is better prepared, peptide therapy is more likely to be useful and less likely to become a wasted resource

Agents such as semaglutide and tirzepatide improve metabolic parameters reliably without worsening baseline inflammatory disease activity ( Signals for disease modification Evidence for true disease modification remains low-certainty and hypothesis-generating, with recent observational signals serving as a foundation for potential disease modification rather than established therapeutic benefit ( A critical real-world evidence (RWE) appraisal of these cohorts reveals significant limitations