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In this study, we highlight the contribution of ser/gly pathway alterations and hyperactivation in promoting an immunosuppressive and aggressive tumor phenotype, causing poor therapeutic responses and outcomes in GBM, which could be improved using combined sertraline/chloroquine treatment

7.3 NETosis-related tubular injury NETosis is a specialized form of neutrophil cell death where neutrophils extrude their nuclear chromatin and granular proteins to form neutrophil extracellular traps (NETs) (218)