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Central nervous system effects may include various degrees of encephalopathy, cognitive and memory deficits, impaired concentration, and diminished executive function

Xiang M, Lu Y, Xin L, Gao J, Shang C, Jiang Z, et al

It is still important for patients taking GLP-1 medication to limit muscle wasting through exercise and high-quality protein. Losing muscle can lower metabolic rate and physical strength

[6] These are minutes, not hours which is why clinical dosing of both has been once-daily subcutaneous injection, and why any marketing that implies a single injection produces long-lasting circulating peptide activity is misleading