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Retatrutide (Future Option) Projected cost: likely $400-$700/month when available Triple-agonist retatrutide awaits FDA approval expected in 2026-2027

Substantial weight regain typically occurs after discontinuing weight loss injections, as demonstrated in clinical trials where patients who stopped semaglutide regained significant weight within one year

Stop the drug, and you get rebound sympathetic activation, typically within 4 to 6 hours of last use, substantially earlier than opioid withdrawal

Thus, following the identification of active BAT in adult humans and the demonstration that certain depots of white adipose tissue can undergo browning, there has been recent interest in the development of approaches that induce BAT activity and promote browning [10]