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Vibet S, Goupille C, Bougnoux P, Steghens JP, Gore J, Maheo K

These reprogrammed MDSCs engulfed tumor cells, co-activated anti-tumor CD8 + T-cell function, and served as professional antigen-presenting cells

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Radiotherapy increases tumor cell ferroptosis susceptibility, significantly inducing the expression of long-chain acyl-CoA synthetase 4 (ACSL4) and the ferroptosis inhibitors SLC7A11 and GPX4, thereby effectively suppressing tumor growth ( Researchers successfully repolarized macrophages from tumor-promoting M2 to anti-tumor M1 phenotype through ferroptosis using MIL88B/RSL3 nanomaterials