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Obes Surg [Internet]
Dominant role of the p110 isoform of PI3K over p110 in energy homeostasis regulation by POMC and AgRP neurons
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While GLP-1R expression in the GI tract is classically ascribed to the myenteric plexus, the highest level of GLP-1R expression in the gut is in the Brunner's glands in the upper duodenum (73, 87)
A history of unsuccessful weight loss attemptsincluding diet, exercise, or other medicationsoften makes someone a candidate for GLP-1 therapy
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