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Importantly, these medications carry a boxed warning for risk of thyroid C-cell tumors and are contraindicated in patients with personal or family history of medullary thyroid carcinoma (MTC) or Multiple Endocrine Neoplasia syndrome type 2 (MEN2)
In summary, alterations at the glutathione activator site result in an absent geometric and electrostatic complementary 3,50 for the reducing agent, explaining the inefficient reduction of numerous glutaredoxins 12,25,26,27,28,29,48 and thioredoxins by GSH
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Gagliardi, M
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