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Preserving muscle while losing fat is a major therapeutic goal in obesity medicine, as loss of muscle mass can worsen metabolic function and long-term outcomes
Severe deficiency causes irreversible neurological damage and subacute combined degeneration of the spinal cord, a condition that does not fully reverse even with aggressive B12 repletion
Mounjaro (tirzepatide) - European Public Assessment Report (EPAR)
Even more interesting is the fact that Shc and PLC were found to only interact with IRS-2 [121]
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