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[17] Testing for the MTHFR Gene and High Homocysteine Levels You can take genetic tests to find out whether you have this gene, as well as high homocysteine levels

6 The four core trials: TRIUMPH-1 (general obesity, 80 weeks): the largest trial in the programme, with nested OSA and OA protocols

Looking at weight-loss thresholds at 80 weeks with 12 mg, nearly all participants lost at least 5% of body weight, and more than 85% lost at least 15%

This is in part because it improves thyroid function and insulin sensitivity

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