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As a result, levels of free leptin were higher in the GLP-1RA group, which may counteract the weight-preserving actions of the physiological leptin decrease during weight loss maintenance as smaller decreases in levels of free leptin would be expected to prevent the leptin-mediated appetite increase and energy expenditure decrease that normally occurs in response to weight loss

International Journal of Epigenetics, 2025;5(1), 1.2 Ajjan RA, Weetman AP