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In atrophying muscles, there is activation of the Forkhead box O transcription factor family (FOXO), as well as NF-B, which can be activated by TNF-, soluble TNF-like weak inducer of apoptosis (TWEAK), or IL-1 [15, 16]

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For general practitioners, the study findings reaffirm the RACGPs and TGAs recent statements advising prescribers to prioritise the use of semaglutide for patients with T2D who are either current users or are previous users and for whom other glucose-lowering medications, including sulfonylureas, dipeptidyl peptidase 4 inhibitors and sodiumglucose cotransporter 2 inhibitors (Table 1), are unsuitable due to refractory or worsening glycaemic control, intolerance or contraindication

The benefits are comparable or superior to the benefits of GLP-1 drugs, including dramatic weight loss and secondary long-term health benefits, such as improved blood sugar levels