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Nevertheless, its clinical translation has been hindered by challenges including poor aqueous solubility, limited cutaneous permeation, and rapid systemic clearance, all of which compromise bioavailability when administered topically
WO patent WO 2020/081973 A1 (2020)
Poliquin says that it's also much easier to use perfect technique in seated movements, noting that cheat curls are often better at building your chiropractor's bank account than your biceps
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