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The steroidal MRAs spironolactone (first generation) and eplerenone (second generation) were the first to enter clinical practice and act as potassium-sparing diuretics with potent antihypertensive effects
This deceleration is expected, not a malfunction
Inspired by this, we hypothesized that this pathway might also mediate YAP1 ubiquitination and stability through NEDD4
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