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Research has investigated whether NNMT inhibition affects adipocyte metabolism, energy expenditure, and body weight in experimental systems

It does not validate the schedule

Some patients feel as though they want more frequent injections, and occasionally we test levels to see if they are receiving adequate replacement, but Im not sure how strong the evidence is to support this. GPs should consider periodic vitamin B12 testing of higher-risk patients who take metformin, even if they dont display symptoms of deficiency, the UK medicines regulator said earlier this year

IM injections allow for slow absorption into the blood, providing a longer-lasting effect