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25.2 months for the PIONEER 6 and SUSTAIN-6 trials, respectively) [35,36], the HR of the PIONEER 6 study may have been statistically significant if the follow-up duration had been longer

There was a significant 24% reduction in the composite primary outcome in the semaglutide group compared with those taking placebo, with first events occurring in 5.8 versus 7.5 people per 100 person-years of follow-up, such that 20 people would need to be treated for 3 years to prevent one primary event