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This remarkable selectivity stems from 5-amino-1MQs specific interaction with the nicotinamide-binding pocket of NNMT, rather than the SAM-binding site common to many methyltransferases

[57] Several serious, even life-threatening diseases cause elevated serum haptocorrin, measured as abnormally high serum vitamin B 12 , while at the same time potentially manifesting as a symptomatic vitamin deficiency because of insufficient vitamin bound to transcobalamin II which transfers the vitamin to cells

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