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Smoking can modulate immune function and increase the production of thyroid-stimulating immunoglobulins, exacerbating the autoimmune process
Bearing this in mind, we postponed appending aspartic acid to a late stage of the synthesis, used only equimolar quantities of N -methylmorpholine (NMM) when a base was required for a reaction, and avoided any base-cleavable protecting groups, such as Fmoc or formyl
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