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NIH describes the cardiovascular implications as uncertain but concerning enough to discuss with a clinician if you have heart disease risk, high LDL cholesterol, kidney disease, or plan to use high doses for months
O.et al (2006)
Microalgae: a potential alternative to health supplementation for humans
The review also documented how GCL expression is transcriptionally upregulated by electrophiles through antioxidant response elements (ARE/EpRE) in the GCLC and GCLM promoters establishing the Nrf2/ARE pathway as the master regulator of GSH biosynthetic capacity under stress conditions
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