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First, we investigated whether NTAPP has a cytotoxic effect by using the 3-(4,5-dimethylthiazol-2-yl)-2, 5-diphenyltetrazolium bromide (MTT) assay at different plasma doses in various exposure time (45, 90, 135, 270 s)
F.KogelK.-H
An elegant study (Gifford et al., 2016) showed that individuals with high CRF (VO 2 max, 59 mlkg 1 min 1 ) have high amounts of mitochondria (i.e., excess), and are far from saturating mitochondrial work capacity even in high-intensity PE
However, when the H 2 O 2 concentration increases because of decreased expression or activity of catalase, it migrates to cytosol and other organelles, causing cell injury and participating in the Fenton reaction, resulting in serious oxidative stress
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