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4a), these data collectively suggest that GLP-1GIPLani enhances body weight loss relative to GLP-1GIP by further accelerating POMC neuronal activity via glutamatergic GLP-1R neurons
The fasting treatment consisted of 2 days with moderate calorie restriction (700800 Kcal/day), 5 days of intense calorie restriction (200 Kcal/day), followed by 3 days with the stepwise reintroduction of a normal diet
ICH Q14 emphasizes analytical procedure development and lifecycle knowledge management for quality-related assessments [14]
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