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4.1 Inflammation Exercise-induced irisin expression is implicated in regulation of several cardiovascular and metabolic conditions, and the therapeutic effect is partly attributed to the anti-inflammatory effects of irisin (Zhang et al., 2016), and/or ROS/NLRP3 inflammasome signaling ( 4.2 Antioxidation (Inhibition of Necrosis and Apoptosis) Irisin plays a protect role against cardiomyocytes and vascular endothelial cells by reducing oxidative stress through AMPK-PI3K-Akt-eNOS-ROS pathway (Wang et al., 2017) Moreover, irisin overexpression or irisin treatment exhibited cardioprotective effect by inhibiting ROS and upregulating expression of antioxidant molecules such as GSH and total SOD in acute and chronic cardiotoxicity models
J Alzheimers Dis 59:537541 Shukla D, Mandal PK, Ersland L, Gruner ER, Tripathi M, Raghunathan P, Sharma A, Chaithya GR, Punjabi K, Splaine C (2018) A Multi-center study on human brain glutathione conformation using magnetic resonance spectroscopy
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