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Biomedical Research 2009
Furthermore, it was found that the luminal pocket binds not only ascorbic acid but also sugars and organic acids contained in food, along with Fe 3+ , promoting the reduction of Fe 3+ (Ganasen et al., 2018)
This accumulation facilitates the binding of -catenin to TCF7L12, triggering the activation of genes associated with osteogenesis.371 In a study examining the effects of GLP-1RA on osteoporosis induced by ovariectomy in aged rats, administering exendin-4 for 16 weeks prevented deterioration of the trabecular microarchitecture and increased bone strength
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