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Serotonin syndrome is relatively uncommon and typically manageable
Several factors limit the accuracy of animal models, including biological differences, artificial experimental conditions, and study design limitations
In contrast, patients using metformin or insulin probably have less or more advanced diabetes, which would increase the risk of unmeasured confounding by diabetes severity and baseline risk of hyperkalemia
Knowing exactly what to do each week, how many units to draw, when to increase, and what to watch for is another thing entirely
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