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The term wasnt widely discussed before TRIUMPH-4 reported in December 2025
The difference from placebo (95% CI) for RYBELSUS 7 mg was -0.9 kg (-1.9, 0.1) and for RYBELSUS 14 mg was -2.3 kg (-3.1, -1.5)
The abdomen typically absorbs medication fastest due to higher vascularity, while the thigh and upper arm provide slightly slower, more steady absorption patterns
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