Finally, a four-year, multicenter, clinical trial in 421 diabetic patients with distal symmetric sensorimotor polyneuropathy found no difference between oral administration of 600 mg/day of lipoic and placebo on the primary endpoint, a composite score that assessed neuropathic impairment of the lower limbs and nerve conduction (78)
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They do not demonstrate receptor activity, hormone effects, safety, or effectiveness
Vitamin E naturally occurs in eight different chemical forms, including alpha-tocopherol and gamma-tocopherol (Albanes 1996