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Physiol Behav (2016) 159:729

However, their activity decreases with aging, creating an imbalance between oxidative damage and repair mechanisms.12 Excessive accumulation of reactive oxygen species (ROS) within hair follicle melanocytes leads to cellular damage through lipid peroxidation, DNA strand breaks, mutations, and protein and enzyme denaturation

B12 deficiency produces a recognizable cluster of symptoms: fatigue, weakness, neurological changes including tingling or numbness in the extremities, cognitive fog, and in more severe cases, megaloblastic anemia

Lee M, Sun J, Han M, et al

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