That suggests the issue may not be a class-wide GLP-1 problem, but rather specific to semaglutide drugs
Furthermore, studies using a peripherally administered exenatide analogue conjugated to vitamin B12, which is sterically hindered from accessing regions protected by the blood brain barrier, improves glucose control in comparable fashion to unmodified exenatide, presumably at the level of the -cell, but does not induce emesis in the house musk shrew ( Suncus murinus) or rats (78, 79)
If you are experiencing significant side effects at 5mg, there is no reason to jump to 7.5mg at exactly the 4-week mark
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