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Lipid accumulation, gene/protein expression, and 5 adenosine monophosphate-activated protein kinase (AMPK) signaling were assessed under lactate exposure, GPR81 knockdown, monocarboxylate transporter 1 (MCT1) inhibition, and AMPK activation conditions

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Then, much like with diphencyclopropenone, the dose was increased on a weekly basis until the patient had a reaction generally landing in the 0.01-1% range