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Concurrently, persistent elevation of fibroblast growth FGF23 not only downregulates CYP27B1 but also induces the catabolic enzyme CYP24A1, accelerating the degradation of active vitamin D and further impairing its biological activity (13)

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Why the FDA Issued Warnings The FDA determined that companies marketing compounded retatrutide: Sold an unapproved new drug without FDA authorization Misbranded products by providing no adequate directions for safe use Improperly claimed compounding exemptions that do not apply to investigational substances In short, these products are not permitted for compounding or distribution under current federal law