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When considering the combination of these medications, several factors should be taken into account: Overlapping side effects Both medications can cause gastrointestinal symptoms, which may be additive when used together
First, they come from different populations and trial designs than the cagrilintide studies SURPASS-2 compared tirzepatide with semaglutide in diabetes
TMF facilitates the nuclear translocation of FoxO3a through the SIRT1/FoxO3a axis, inhibits the expression of ADAMTSs, reduces matrix degradation, and suppresses cartilage hypertrophy (65, 71)
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