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48 Similar results were obtained in a hGLP-1R knock-in murine model in which the administration of Danuglipron resulted in an overall improvement of glucose tolerance and food intake reduction, thus opening the possibility to use an effective oral GLP-1RA

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17 ) Besttigt werden diese Annahmen durch ein Muse-Modell, bei dem die muskelspezifische CrAT (Carnitin-Acyltransferase) fehlt: Es zeigt sich eine dramatisch eingeschrnkte metabolische Flexibilitt, vor allem beim Switch vom Fett- auf den Kohlenhydratstoffwechsel

The clinical course was correlated with magnetic resonance imaging and multimodal evoked potential findings, but not with ammonia levels