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This binding induces a conformational change in MTF-1, enabling it to translocate from the cytoplasm to the nucleus

Particularly noteworthy is that FOXO4 influences not only lifespan but also the quality of aging through its interaction with the protein p53commonly referred to as the "guardian of the genome." This interaction regulates whether cells remain in a senescent, metabolically inactive state or undergo programmed cell death (apoptosis)

Further, it upregulates multiple growth receptors in the body and stimulates the production of fibroblasts, vital to the synthesis of collagen

Glutathione in Brain Disorders and Aging